Asians must be screened for diabetes at lower fat levels — experts

ALEXANDRIA, Virginia — Evidence that many Asian Americans develop the diabetes at lower Body Mass Index (BMI) levels than the general population, the American Diabetes Association is lowering the BMI cut point at which it recommends screening Asian Americans for type 2 diabetes.

This new guideline is aligned with the position statement published in the January issue of Diabetes Care.

“The position statement highlights, for the first time, the physiologic differences seen between Asian Americans and other populations affected by diabetes,” said Jane Chiang, ADA’s senior vice president for Medical Affairs and Community Information.

“Asian Americans are a heterogeneous group and have historically been underrepresented in studies, so it is important to keep in mind that this is just the beginning. Clearly, we need more research to better understand why these distinctions exist,” Chiang added.

For members of the general population, the ADA recommends testing for diabetes when BMI reaches 25 kg/m2 or higher. Based on an exhaustive review of the literature, for Asian Americans, it is now recommending that screening be done at 23 kg/m2 or higher.

It is believed that Asian Americans – the nation’s fastest growing ethnic group – develop diabetes at lower BMI levels because of differences in their body composition: weight gain tends to accumulate around the waist in Asian Americans, the area in which adiposity is considered most harmful from a disease standpoint, rather than in the thighs and other parts of the body.

“Clinicians have known this intuitively for quite some time,” said William C. Hsu, M.D., vice president, International Programs, Joslin Diabetes Center and assistant professor, Harvard Medical School, who was lead author of the position paper.

“They can see that Asian Americans are being diagnosed with diabetes when they do not appear to be overweight or obese according to general standards. But if you use the previous Association standard for diabetes screening of being age 45 or older with a BMI of 25 kg/m2 or above, you will miss many Asian Americans who are at risk,” Hsu explained.

The Asian Americans Native Hawaiian and Pacific Islander (AANHPI) Diabetes Coalition began drawing attention to the need for changes in clinical management guidelines for Asian Americans, who experience twice the prevalence of type 2 diabetes than Caucasian Americans despite having lower rates of obesity under current federal BMI standards, following a 2011 State of the Science Scientific Symposium on Diabetes in Hawaii.

“Research has shown that BMI may not be the best marker in this population.  This paper is a significant step in the right direction of widely recognizing the diabetes disparity that exists in our populations and communities,” said Ho Luong Tran, M.D., president of the National Council of Asian Pacific Islander Physicians, and lead coordinator of the AANHPI Diabetes Coalition.

“The next steps are to increase the amount of clinical research and data on this diverse population, while simultaneously pushing for policy change that will positively impact health outcomes,” Tran added.

The ADA’s position statement does not redefine overweight or obesity for Asian Americans, only the BMI cut point for screening for type 2 diabetes.

“What this does is to help us, as a society, identify those who are at risk for type 2 diabetes who might otherwise not have been identified because of their lack of appearance of obesity,” said Hsu, adding that the growing prevalence of diabetes and its economic impact in the United States heighten the need for early detection and prevention.

For a copy of the Association’s position statement, or to obtain a copy, visit https://dx.doi.org/10.2337/dc14-2391.